Recent applications of <i>N</i>-acyl imidazole chemistry in chemical biology

Chemical genetics: reshaping biology through chemistry.

To understand biological processes, biologists typically study how perturbations of protein functions affect the phenotype. Protein activity in living cells can be influenced in many different ways: by manipulation of the genomic information, by injecting inhibitory antibodies, or, more recently, by the use of ribonucleic acid-medicated interference (RNAi). All these methods have proven to be e...

Chemical biology: Chromatin chemistry goes cellular.

Chemical biology meets biological chemistry minireview series.

What is the difference between “biological chemistry” and “chemical biology?” One of us (J. M. G.) received his Ph.D. at an institution where the biochemistry building was called the Laboratory of Chemical Biology, but that was a long time ago, and things have changed. Biological chemistry (or biochemistry), that is the study of life processes at the molecular level, is now quite distinct from ...

Recent developments in the chemistry and biology of epothilones

Epothilones (Epo’s) are bacterial natural products which are potent inhibitors of human cancer cell proliferation in vitro and in vivo. Tumor growth inhibition is based on the stabilization of cellular microtubules and at least seven epothilone-derived agents are presently undergoing clinical evaluation in humans. While all of these compounds are closely related structurally to the natural prod...

Applications of microfluidics in chemical biology.

This review discusses the application of microfluidics in chemical biology. It aims to introduce the reader to microfluidics, describe characteristics of microfluidic systems that are useful in studying chemical biology, and summarize recent progress at the interface of these two fields. The review concludes with an assessment of future directions and opportunities of microfluidics in chemical ...